Author/Authors :
Alan E. Moormann، نويسنده , , Sue Metz، نويسنده , , Mihaly V. Toth، نويسنده , , William M. Moore، نويسنده , , Gina Jerome، نويسنده , , Christine Kornmeier، نويسنده , , Pamela Manning، نويسنده , , Donald W. Hansen Jr.، نويسنده , , Barnett S. Pitzele، نويسنده , , R. K. Webber، نويسنده ,
Abstract :
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50ʹs) for these inhibitors are in the low micromolar range for hi-NOS with some examples exhibiting a 500× selectivity versus hec-NOS.
