Title of article :
Synthesis of diaminobutane derivatives as potent Ca2+-Permeable AMPA receptor antagonists
Author/Authors :
Yoshiyuki Yoneda، نويسنده , , Shinichi Kawajiri، نويسنده , , Masunobu Sugimura، نويسنده , , Ken Osanai، نويسنده , , Fusako Kito، نويسنده , , Emi Ota، نويسنده , , Tetuya Mimura، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
4
From page :
2663
To page :
2666
Abstract :
We synthesized diaminobutane derivatives as potent Ca2+-permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca2+-permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2001
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
791703
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791703
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