Title of article
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
Author/Authors
Lei Ling، نويسنده , , Liana J. Urichuk، نويسنده , , B. Duff Sloley، نويسنده , , Ronald T. Coutts، نويسنده , , Glen B. Baker، نويسنده , , Jacqueline J. Shan، نويسنده , , Peter K. T. Pang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2715
To page
2717
Abstract
A series of N1- and N2-propargylphenelzine derivatives and analogues (1–7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N1- and N2-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791714
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