Author/Authors :
Lei Ling، نويسنده , , Liana J. Urichuk، نويسنده , , B. Duff Sloley، نويسنده , , Ronald T. Coutts، نويسنده , , Glen B. Baker، نويسنده , , Jacqueline J. Shan، نويسنده , , Peter K. T. Pang، نويسنده ,
Abstract :
A series of N1- and N2-propargylphenelzine derivatives and analogues (1–7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N1- and N2-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
