Title of article
α-Alkyl-α-amino-β-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1
Author/Authors
Daniel P. Becker، نويسنده , , Gary DeCrescenzo، نويسنده , , John Freskos، نويسنده , , Daniel P. Getman، نويسنده , , Susan L. Hockerman، نويسنده , , Madeleine Li، نويسنده , , Pramod Mehta، نويسنده , , Grace E. Munie، نويسنده , , Craig Swearingen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2723
To page
2725
Abstract
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected compounds were orally bioavailable.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791716
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