Author/Authors :
Daniel P. Becker، نويسنده , , Gary DeCrescenzo، نويسنده , , John Freskos، نويسنده , , Daniel P. Getman، نويسنده , , Susan L. Hockerman، نويسنده , , Madeleine Li، نويسنده , , Pramod Mehta، نويسنده , , Grace E. Munie، نويسنده , , Craig Swearingen، نويسنده ,
Abstract :
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected compounds were orally bioavailable.
