Author/Authors :
William R. Roush.، نويسنده , , Jianming Cheng، نويسنده , , Beth Knapp-Reed، نويسنده , , Alejandro Alvarez-Hernandez، نويسنده , , Andrej Sali and James H. McKerrow، نويسنده , , Elizabeth Hansell، نويسنده , , Juan C. Engel، نويسنده ,
Abstract :
A new family of potent N-alkoxyvinylsulfonamide inhibitors of cruzain have been developed. Inhibitor 13 has a second order inactivation rate constant of 6,480,000 s−1 M−1 versus cruzain, and is also highly effective against Trypanosoma cruzi trypomastigotes in a tissue culture assay.
