Author/Authors :
Aurash B. Shahripour، نويسنده , , Mark S. Plummer، نويسنده , , Elizabeth A. Lunney، نويسنده , , Tomi K. Sawyer، نويسنده , , Charles J. Stankovic، نويسنده , , Michael K. Connolly، نويسنده , , John R. Rubin، نويسنده , , Nigel P. C. Walker، نويسنده , , Kenneth D. Brady، نويسنده , , Hamish J. Allen، نويسنده , , Robert V. Talanian، نويسنده , , Winnie W. Wong، نويسنده , , Christine Humblet، نويسنده ,
Abstract :
A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.
