Author/Authors :
Steven M. Bromidge، نويسنده , , Kerry Griffith، نويسنده , , Tom D. Heightman، نويسنده , , Andrew Jennings، نويسنده , , Frank D. King، نويسنده , , Stephen F. Moss، نويسنده , , Helen Newman-Gage، نويسنده , , Graham Riley، نويسنده , , Carol Routledge، نويسنده , , Halina T. Serafinowska، نويسنده , , David R. Thomas، نويسنده ,
Abstract :
The discovery of (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides and their binding affinites for a selection of 5-HT and dopamine subreceptors is described. Many compounds show high afffinity (pKi>8) for the 5-HT6 receptor and >100-fold selectivity against a range of other receptors. Structure–activity relationships of these compounds are discussed.
