Title of article
Design and synthesis of pfmrk inhibitors as potential antimalarial agents
Author/Authors
Zili Xiao، نويسنده , , Norman C. Waters، نويسنده , , Cassandra L. Woodard، نويسنده , , Zhiyu Li، نويسنده , , Pui-Kai Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2875
To page
2878
Abstract
The synthesis and inhibitory activities of 10 potential inhibitors of Pfmrk, a Plasmodium falciparum cyclin-dependent protein kinase, are described. The most potent inhibitor is a 3-phenyl-quinolinone compound with an IC50 value of 18 μM. It is the first compound reported to inhibit Pfmrk at the micro molar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791750
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