Author/Authors :
Atli Thorarensen، نويسنده , , Gary E. Zurenko، نويسنده , , Michael T. Sweeney، نويسنده , , Keith R. Marotti، نويسنده , , Timothy P. Boyle، نويسنده ,
Abstract :
This paper describes the discovery of α-trifluoroketoacetamides as potent antibacterial agents against Gram-positive organisms. The initial SAR indicates that the aryl ethyl side chain is essential in maintaining antibacterial activity. The SAR observations have been utilized to design a bioisostere for the α-trifluoroketoacetamide with good activity against Gram-positive organisms.
