• Title of article

    Enols as Potent Antibacterial Agents

  • Author/Authors

    Atli Thorarensen، نويسنده , , Gary E. Zurenko، نويسنده , , Michael T. Sweeney، نويسنده , , Keith R. Marotti، نويسنده , , Timothy P. Boyle، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    2931
  • To page
    2934
  • Abstract
    This paper describes the discovery of α-trifluoroketoacetamides as potent antibacterial agents against Gram-positive organisms. The initial SAR indicates that the aryl ethyl side chain is essential in maintaining antibacterial activity. The SAR observations have been utilized to design a bioisostere for the α-trifluoroketoacetamide with good activity against Gram-positive organisms.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791763

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791763