Title of article
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism
Author/Authors
A. S. M. Sabbir Ahmed، نويسنده , , Karen James، نويسنده , , Caroline P. Owen، نويسنده , , Chirag K. Patel، نويسنده , , Mijal B. Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
3001
To page
3005
Abstract
Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791779
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