Title of article
Hydrolysis of linear DNA duplex catalyzed by Co(III) complex of cyclen attached to polystyrene
Author/Authors
Chul-Seung Jeung، نويسنده , , Jung Bae Song، نويسنده , , Yong-Hyun Kim، نويسنده , , Junghun Suh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
3061
To page
3064
Abstract
To design artificial restriction enzymes, synthetic catalytic centers that effectively hydrolyze linear double-stranded polydeoxyribonucleotides are needed. The Co(III) complex of cyclen (CoCyc) attached to polystyrene derivatives hydrolyzes linearized pUC18 DNA with half-lives as short as 30 min at 25 °C. The catalytic activity of CoCyc is enhanced by >150 times on attachment to the resin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791792
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