Title of article
Flavonoids: structural requirements for antiproliferative activity on breast cancer cells
Author/Authors
Christelle Pouget، نويسنده , , Fabienne Lauthier، نويسنده , , Alain Simon، نويسنده , , Catherine Fagnere، نويسنده , , Jean-Philippe Basly، نويسنده , , Christiane Delage، نويسنده , , Albert-José Chulia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
3095
To page
3097
Abstract
Several classes of flavonoids (flavones, flavanones, 2′-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure–activity relationships of these compounds were discussed. 2′-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791801
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