Title of article
Synthesis and anti-HIV activity of oleanolic acid derivatives
Author/Authors
Yong-Ming Zhu، نويسنده , , Jing-Kang Shen، نويسنده , , Hui-Kang Wang، نويسنده , , L. Mark Cosentino، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
3115
To page
3118
Abstract
Thirteen oleanolic acid derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Saturating the C12–C13 double bond and converting the C17-carboxyl group to an aminomethyl group led to compounds 13– 15 and 19– 20, respectively, which showed improved anti-HIV activity. Compound 15 was the most potent derivative with EC50=0.0039 μg/mL and TI=3570.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791805
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