Author/Authors :
Vincenzo Santagada، نويسنده , , Giuseppe Caliendo، نويسنده , , Beatrice Severino، نويسنده , , Elisa Perissutti، نويسنده , , Ferdinando Fiorino، نويسنده , , Carla Cicala، نويسنده , , Vincenzo De Filippis، نويسنده , , Giuseppe Cirino، نويسنده ,
Abstract :
Protease-activated receptor 2 (PAR-2) is involved in inflammatory, gastrointestinal, and vascular diseases. The aim of the present work was to elucidate the minimal structural features for PAR-2 agonist activity in short peptides. Our study resulted in the discovery of dipeptide derivatives of Nα-benzoyl-Arg(NO2)-Leu-NH2 displaying a potency comparable to that of the full-length rat PAR-2 activating peptide (Ser-Leu-Ile-Gly-Arg-Leu-NH2).
