Title of article
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues
Author/Authors
Jagabandhu Das، نويسنده , , S. David Kimball، نويسنده , , Joyce A. Reid، نويسنده , , Tammy C. Wang، نويسنده , , Wan F. Lau، نويسنده , , Daniel G. M. Roberts، نويسنده , , Steven M. Seiler، نويسنده , , William A. Schumacher، نويسنده , , Martin L. Ogletree، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
41
To page
44
Abstract
A series of structurally novel small molecule inhibitors of human α-thrombin was prepared to elucidate their structure– activity relationships (SAR), selectivity and activity in vivo. BMS-189090 (5) is identified as a potent, selective, and reversible inhibitor of human α-thrombin that is efficacious in vivo in a mice lethality model, and in inhibiting both arterial and venous thrombosis in a rat model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791886
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