New readily accessible peroxides with High Anti-malarial Potency

In an explorative study for new anti-malarial substances using the methyl esters (1 and 2) of peroxyplakoric acids A3 and B3 as scaffolds, 6-carbomethoxymethyl-3-methoxy-3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-α,β-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.