Author/Authors :
Hiroyuki Miyachi، نويسنده , , Masahiro Nomura، نويسنده , , Takahiro Tanase، نويسنده , , Yukie Takahashi، نويسنده , , Tomohiro Ide، نويسنده , , Masaki Tsunoda، نويسنده , , Koji Murakami، نويسنده , , Katsuya Awano، نويسنده ,
Abstract :
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure–activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
