Title of article
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARα-selective activators
Author/Authors
Hiroyuki Miyachi، نويسنده , , Masahiro Nomura، نويسنده , , Takahiro Tanase، نويسنده , , Yukie Takahashi، نويسنده , , Tomohiro Ide، نويسنده , , Masaki Tsunoda، نويسنده , , Koji Murakami، نويسنده , , Katsuya Awano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
77
To page
80
Abstract
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure–activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791895
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