Title of article
The design and synthesis of a novel series of indole derived selective ETA antagonists
Author/Authors
David J. Rawson، نويسنده , , Kevin N. Dack، نويسنده , , Roger P. Dickinson، نويسنده , , Kim James، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
125
To page
128
Abstract
Conformational constraint has been used as the key design element in the identification of a series of potent and selective ETA antagonists. The most potent antagonist, 32, (ETA IC50=0.55 nM) is 722-fold selective over the ETB receptor, as measured by binding experiments.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791913
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