Title of article :
Synthesis and structure–Activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 2
Author/Authors :
J. Ignacio Andrés، نويسنده , , Jes?s Alc?zar، نويسنده , , José M. Alonso-Meijide، نويسنده , , Adolfo D?az، نويسنده , , Javier Fernandez-Suarez، نويسنده , , M. Pilar Gil، نويسنده , , Laura Iturrino، نويسنده , , Encarna Matesanz، نويسنده , , Theo F. Meert، نويسنده , , Anton Megens، نويسنده , , Victor K. Sipido، نويسنده ,
Abstract :
Following the programme started at Janssen Research Foundation searching for 5-HT2A/2C antagonists, we now report on the synthesis of a series of substituted 2-(Dimethylaminomethyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives. The 5-HT2A, 5-HT2C and H1 receptor affinities as well as the mCPP antagonistic activity of the compounds synthesised is described.
