Title of article
Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative
Author/Authors
David Egron، نويسنده , , Christian Perigaud، نويسنده , , Gilles Gosselin، نويسنده , , Anne-Marie Aubertin، نويسنده , , Hiroyuki Gatanaga، نويسنده , , Hiroaki Mitsuya، نويسنده , , Jiri Zemlicka، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
2
From page
265
To page
266
Abstract
The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4′-hydroxy-1′,2′-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791949
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