Author/Authors :
David Egron، نويسنده , , Christian Perigaud، نويسنده , , Gilles Gosselin، نويسنده , , Anne-Marie Aubertin، نويسنده , , Hiroyuki Gatanaga، نويسنده , , Hiroaki Mitsuya، نويسنده , , Jiri Zemlicka، نويسنده , , Jean-Louis Imbach، نويسنده ,
Abstract :
The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4′-hydroxy-1′,2′-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.
