Title of article
Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-Guided ligand assembly
Author/Authors
John W. Kehoe، نويسنده , , Dustin J. Maly، نويسنده , , Dawn E. Verdugo، نويسنده , , Joshua I. Armstrong، نويسنده , , Brian N. Cook، نويسنده , , Ying-Bin Ouyang، نويسنده , , Kevin L. Moore، نويسنده , , Jonathan A. Ellman، نويسنده , , C.R.Carolyn R. Bertozzi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
329
To page
332
Abstract
Tyrosylprotein sulfotransferases (TPSTs) catalyze the sulfation of tyrosine residues within secreted and membrane-bound proteins. The modification modulates protein–protein interactions in the extracellular environment. Here we use combinatorial target-guided ligand assembly to discover the first known inhibitors of human TPST-2.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791965
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