Title of article
Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids
Author/Authors
Iwao Ojima، نويسنده , , Xudong Geng، نويسنده , , Songnian Lin، نويسنده , , Paula Pera، نويسنده , , Ralph J. Bernacki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
349
To page
352
Abstract
A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09–0.3 μM IC50 values.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791970
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