Author/Authors :
Guy Lewin، نويسنده , , Reynald Hocquemiller، نويسنده , , Corinne Schaeffer، نويسنده , , Pierre-Hervé Lambert، نويسنده , , Stephane Leonce، نويسنده , , Alain Pierré، نويسنده ,
Abstract :
Eight analogues of (−)-16-chloro-1-dehydro-6S-bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure–activity relationships within this series.
