Title of article
A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor
Author/Authors
Satoshi Sunami، نويسنده , , Mitsuru Ohkubo، نويسنده , , Takeshi Sagara، نويسنده , , Jun Ono، نويسنده , , Shuichi Asahi، نويسنده , , Seita Koito، نويسنده , , Hajime Morishima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
629
To page
632
Abstract
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792033
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