An additional 2′-ribofuranose residue at a specific position of the DNA primer prevents Its elongation by HIV-1 reverse transcriptase
Author/Authors :
O. I. Andreeva، نويسنده , , A. S. Golubeva، نويسنده , , S. N. Kochetkov، نويسنده , , A. Van Aerschot، نويسنده , , P. Herdewijn، نويسنده , , E. V. Efimtseva، نويسنده , , B. S. Ermolinsky، نويسنده , , S. N. Mikhailov، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
4
From page :
681
To page :
684
Abstract :
Oligodeoxynucleotides containing 2′-O-β- -ribofuranosyladenosine were prepared and used as modified primers in RNA-templated DNA synthesis catalyzed by HIV reverse transcriptase. It was shown that the additional 2′-ribofuranose residue in specific position of primer prevents its elongation.
