Author/Authors :
Charles J. McIntyre، نويسنده , , Gerald S. Ponticello، نويسنده , , Nigel J. Liverton، نويسنده , , Stephen J. O’Keefe، نويسنده , , Edward A. O’Neill، نويسنده , , Margaret Pang، نويسنده , , Cheryl D. Schwartz، نويسنده , , David A. Claremon، نويسنده ,
Abstract :
Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38 MAPK. The most active isomers were those possessing an aryl group α and a heteroaryl group β relative to the nitrogen atom in the 2-position of the central pyridazine. Additionally, substitution in the 6-position of the central pyridazine with a variety of dialkylamino substituents afforded a set of inhibitors having good (p38 IC50 1–20 nM) in vitro activity.
