Author/Authors :
Nicholas J. S. Harmat، نويسنده , , Danilo Giannotti، نويسنده , , Rossano Nannicini، نويسنده , , Enzo Perrotta، نويسنده , , Marco Criscuoli، نويسنده , , Riccardo Patacchini، نويسنده , , Anna-Rita Renzetti، نويسنده , , Sandro Giuliani، نويسنده , , Maria Altamura، نويسنده , , Carlo A. Maggi، نويسنده ,
Abstract :
A series of cyclic pseudopeptides were synthesized containing the sequence -Trp-Phe-( )-PheΨCH2NH-, the terminal ends of which were bound to 2-carboxy succinate or enantiomerically enriched tricarballylic acid to give the final cyclic structures. These two molecules and their subsequent derivatives were screened for h-NK2 receptor binding and functional antagonist activity on the rabbit urinary bladder.
