Title of article
Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease
Author/Authors
Stefania Colarusso، نويسنده , , Benjamin Gerlach، نويسنده , , Uwe Koch، نويسنده , , Ester Muraglia، نويسنده , , Immacolata Conte، نويسنده , , Ian Stansfield، نويسنده , , Victor G. Matassa، نويسنده , , Frank Narjes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
705
To page
708
Abstract
N-Terminal truncation of the hexapeptide ketoacid 1 gave rise to potent tripeptide inhibitors of the hepatitis C virus NS3 protease/NS4A cofactor complex. Optimization of these tripeptides led to ketoacid 30 with an IC50 of 0.38 μM. The SAR of these tripeptides is discussed in the light of the recently published crystal structures of a ternary tripetide/NS3/NS4A complexes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792052
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