Author/Authors :
Ioanna-Maria Karaguni، نويسنده , , Karl-Heinz Glüsenkamp، نويسنده , , Anette Langerak، نويسنده , , Christoph Geisen، نويسنده , , Volker Ullrich، نويسنده , , Günther Winde، نويسنده , , Tarik M?r?y، نويسنده , , Oliver Müller، نويسنده ,
Abstract :
Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.
