N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists
Author/Authors :
George A. Doherty، نويسنده , , Theodore Kamenecka، نويسنده , , Ermenegilda McCauley، نويسنده , , Gail Van Riper، نويسنده , , Richard A. Mumford، نويسنده , , Sharon Tong، نويسنده , , William K. Hagmann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
3
From page :
729
To page :
731
Abstract :
A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4.
