Author/Authors :
Thomas E. Renau، نويسنده , , Roger Léger، نويسنده , , Rose Yen، نويسنده , , Miles W. She، نويسنده , , Eric M. Flamme، نويسنده , , Joan Sangalang، نويسنده , , Carla L. Gannon، نويسنده , , Suzanne Chamberland، نويسنده , , Olga Lomovskaya، نويسنده , , Ving J. Lee، نويسنده ,
Abstract :
Several classes of peptidomimetics of the efflux pump inhibitor -ornithine- -homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead, demonstrating that a peptide backbone is not essential for activity.
