Author/Authors :
Satoru Kaneko، نويسنده , , Takuya Uchida، نويسنده , , Satoshi Shibuya، نويسنده , , Takeshi Honda، نويسنده , , Isao Kawamoto، نويسنده , , Tamako Harasaki، نويسنده , , Takashi Fukuoka، نويسنده , , Toshiyuki Konosu، نويسنده ,
Abstract :
Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (≤0.125 μg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC ≤0.125 μg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans.
