Author/Authors :
Alessandra Ammazzalorso، نويسنده , , Rosa Amoroso، نويسنده , , Mario Baraldi، نويسنده , , Giancarlo Bettoni، نويسنده , , Daniela Braghiroli، نويسنده , , Barbara De Filippis، نويسنده , , Andrea Duranti، نويسنده , , Marco Moretti، نويسنده , , Paolo Tortorella، نويسنده , , Maria Luisa Tricca، نويسنده , , Francesca Vezzalini، نويسنده ,
Abstract :
The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency.
