Author/Authors :
Timothy A. Blizzard، نويسنده , , Ronald M. Kim، نويسنده , , Jerry D. Morgan، نويسنده , , II، نويسنده , , Sheng-Jiang Chang، نويسنده , , Joyce Kohler، نويسنده , , Ruth Kilburn، نويسنده , , Kevin Chapman، نويسنده , , Milton L. Hammond، نويسنده ,
Abstract :
A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were essentially inactive against vanA phenotype VREF strains but retained substantial activity against other bacteria, a profile reminiscent of teicoplanin.
