Title of article
Imidazo[5,1-f][, and ]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors
Author/Authors
Helmut Haning، نويسنده , , Ulrich Niew?hner، نويسنده , , Thomas Schenke، نويسنده , , Mazen Es-Sayed، نويسنده , , Gunter Schmidt، نويسنده , , Thomas Lampe، نويسنده , , Erwin Bischoff، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
865
To page
868
Abstract
2-aryl-substituted imidazo[5,1-f][1,2,4]triazin-4(3H)-ones represent a new class of potent cGMP-PDE 5 inhibitors that prove to be superior to other purine-isosteric inhibitors. Subnanomolar inhibitors of PDE 5 with activity in in vivo models for erectile dysfunction have been identified. BAY 38-9456 (Vardenafil-hydrochloride) has been selected for clinical studies in the indication of erectile dysfunction.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792087
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