Author/Authors :
Anton Copar، نويسنده , , Tadeja Prevec، نويسنده , , Borut An i ، نويسنده , , Toma Mesar، نويسنده , , Lovro Seli ، نويسنده , , Mateja Vilar، نويسنده , , Tom Solmajer، نويسنده ,
Abstract :
Known carbapenem compounds with inhibitory effect towards β-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.
