Title of article
Antitumor agents. Part 3: synthesis and cytotoxicity of new trans-Stilbene benzenesulfonamide derivatives
Author/Authors
Liming Yang، نويسنده , , Shwu-Jiuan Lin، نويسنده , , Fen-Lin Hsu، نويسنده , , Tsang-Hsiung Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
1013
To page
1015
Abstract
A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Instituteʹs 60 human tumor cell line in vitro screen. Compounds 9–13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT–29 colon cancer (GI50=0.554 μM), respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792124
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