N-Alkylaminoacids and Their derivatives interact with melanocortin receptors

Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, and ) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC1,3–5 reaching the low micromolar range.