Author/Authors :
Patrizia Alberti، نويسنده , , Philippe Schmitt، نويسنده , , Chi Hung Nguyen، نويسنده , , Christian Rivalle، نويسنده , , Magali Hoarau، نويسنده , , David S. Grierson and Robert W. Carpick، نويسنده , , Jean-Louis Mergny، نويسنده ,
Abstract :
Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro.
