Title of article :
A 3,4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit
Author/Authors :
Kazuyuki Miyashita، نويسنده , , Myunji Park، نويسنده , , Sayako Adachi، نويسنده , , Sayori Seki، نويسنده , , Satoshi Obika، نويسنده , , Takeshi Imanishi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
