Title of article
Sulfide analogues as potent and selective M2 muscarinic receptor antagonists
Author/Authors
Yuguang Wang، نويسنده , , Samuel Chackalamannil، نويسنده , , Zhiyong Hu، نويسنده , , Brian A. McKittrick، نويسنده , , William Greenlee، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Jean E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
1087
To page
1091
Abstract
We have discovered highly potent, selective sulfide M2 receptor antagonists with low molecular weight and different structural features compared with our phase I clinical candidate Sch 211803. Analogue 30 showed superior M2 receptor selectivity profile over Sch 211803. More importantly, this study provided new leads for the discovery of M2 receptor antagonists as potential drug candidates.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792147
Link To Document