Title of article
Benzobicyclooctanes as novel inhibitors of TNF-α signaling
Author/Authors
Randy W. Jackson، نويسنده , , Richard Gelinas، نويسنده , , Ted A. Baughman، نويسنده , , J. Thomas Cox، نويسنده , , J. Jeffry Howbert، نويسنده , , Kristin A. Kucera، نويسنده , , John A. Latham، نويسنده , , Fred Ramsdell، نويسنده , , Devinder Singh ، نويسنده , , Ihab S. Darwish، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
1093
To page
1097
Abstract
A novel series of TNF-α inhibitors based on a benzobicyclooctane scaffold is reported. The compounds display good potency in inhibiting TNF-α induced apoptosis and NFκB activation. Additionally, they are selective for TNF-α as they do not inhibit apoptosis induced by soluble Fas ligand. The compounds described here can act as leads for future medicinal chemistry efforts and may also be useful tools for elucidating the TNF-α signaling pathway.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792148
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