Title of article
Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase. Part 2: Solid-Phase optimization of side chains
Author/Authors
Sharon M. Dankwardt، نويسنده , , Sarah C. Abbot، نويسنده , , Chris A. Broka، نويسنده , , Robert L. Martin، نويسنده , , Christine S. Chan، نويسنده , , Eric B. Springman، نويسنده , , Harold E. Van Wart، نويسنده , , Keith A. M. Walker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
1233
To page
1235
Abstract
Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were discovered to be PCP inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792183
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