Title of article
Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
Author/Authors
Pierre Deprez، نويسنده , , Eliane Mandine، نويسنده , , Dominique Gofflo، نويسنده , , Stéphane Meunier، نويسنده , , Dominique Lesuisse، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1295
To page
1298
Abstract
Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792199
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