Author/Authors :
Mi Young Cha، نويسنده , , Byung Chul Choi، نويسنده , , Kyung Ho Kang، نويسنده , , Ae Nim Pae، نويسنده , , Kung Il Choi، نويسنده , , Yong Seo Cho، نويسنده , , Hun Yeong Koh، نويسنده , , Hee-Yoon Lee، نويسنده , , Daeyoung Jung، نويسنده , , Jae Yang Kong، نويسنده ,
Abstract :
A piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D2, D3, and D4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D3 and D4 receptors over the D2 receptor. Compounds 6s and 6t showed Ki values of 2.6 nM and 3.9 nM for the D3 receptor with 46- and 50-fold selectivity over the D2 receptor, respectively.
