Title of article
Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen
Author/Authors
Byeoung-Soo Park، نويسنده , , Dae-Young Kim، نويسنده , , Philip J. Rosenthal، نويسنده , , Sun-Chul Huh، نويسنده , , Belinda J. Lee، نويسنده , , Eun-Ju Park، نويسنده , , Sung-Min Kim، نويسنده , , Jang-Eok Kim، نويسنده , , Mi-Hee Kim، نويسنده , , Tae-Lin Huh، نويسنده , , Young-Jae Choi، نويسنده , , Ki-Hyung Suh، نويسنده , , Won-Sik Choi، نويسنده , , Sung-Eun Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
1351
To page
1355
Abstract
In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792214
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