Title of article
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists
Author/Authors
Steven M. Bromidge، نويسنده , , Stephen E. Clarke، نويسنده , , Frank D. King، نويسنده , , Peter J. Lovell، نويسنده , , Helen Newman-Gage، نويسنده , , Graham Riley، نويسنده , , Carol Routledge، نويسنده , , Halina T. Serafinowska، نويسنده , , Douglas R. Smith، نويسنده , , David R. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1357
To page
1360
Abstract
The synthesis of novel 3-(octahydropyrido[1,2-a]pyrazin-2-yl)- and 3-(hexahydropyrrolo[1,2-a]pyrazin-2-yl)phenyl-2-benzo[b]thiophene sulphonamide derivatives 3, (S)-4 and (R)-4 is described. The compounds show high affinity for the 5-HT6 receptor, excellent selectivity against a range of other receptors and good brain penetration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792215
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