Title of article
Synthesis of highly potent and selective hetaryl ureas as integrin αVβ3-Receptor antagonists
Author/Authors
Udo E. W. Lange، نويسنده , , Gisela Backfisch، نويسنده , , Jürgen Delzer، نويسنده , , Hervé Geneste، نويسنده , , Claudia Graef، نويسنده , , Wilfried Hornberger، نويسنده , , Andreas Kling، نويسنده , , Arnulf Lauterbach، نويسنده , , Thomas Subkowski، نويسنده , , Christian Zechel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1379
To page
1382
Abstract
Solid-phase synthesis and SAR of integrin αVβ3-receptor antagonists containing a urea moiety as non-basic guanidine mimetic are described. The most potent compounds exhibited IC50 values towards αVβ3 in the nanomolar range and high selectivity versus related integrins like αIIbβ3. For selected examples efficacy in functional cellular assays is demonstrated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792220
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