Author/Authors :
Paul G. Wyatt، نويسنده , , Michael J. Allen، نويسنده , , Josie Chilcott، نويسنده , , Alison Foster، نويسنده , , David G. Livermore، نويسنده , , Jackie E. Mordaunt، نويسنده , , Jan Scicinski، نويسنده , , Patrick M. Woollard، نويسنده ,
Abstract :
Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.
