Author/Authors :
Irene Drizin، نويسنده , , Mark W. Holladay، نويسنده , , Hua-Lin Yi، نويسنده , , Henry Q. Zhang، نويسنده , , Sujatha Gopalakrishnan، نويسنده , , Murali Gopalakrishnan، نويسنده , , Kristi L. Whiteaker، نويسنده , , Steven A. Buckner، نويسنده , , James P. Sullivan، نويسنده , , William A. Carroll، نويسنده ,
Abstract :
A novel series of tricyclic dihydropyrimidines was synthesized and evaluated for activity as KATP channel openers. The functional activity of several compounds, for example 6A (EC50=30 nM) and its enantiomers exceeded cromakalim.
